翁壯鋒

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翁壯鋒

2009年9月至20136月,就讀于南方醫科大學生物技術學院,獲理學學士學位。20139月至20186月在中國科學院上海生命科學研究院上海生物化學與細胞生物學研究所張榮光研究員課題組從事結構生物學研究,獲理學博士學位。

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研究經歷

(1)KANK1/KIF21A 復合物在細胞皮層與細胞骨架相互關聯中的結構生物學研究

(2)支架蛋白MAGI 介導的蛋白復合物在腎病綜合癥發病機制中的結構與功能研究

(3)Adhesion GPCRs BAI亞家族相關信號通路的結構與功能研究

著作

1. Weng, Z., Shang, Y., Yao, D., Zhu, J., and Zhang, R. (2018). Structural analyses of key features in the KANK1.KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex. The Journal of biological chemistry?293, 215-225.

2. Weng, Z., Shang, Y., Ji,Z, Ye,F, Lin,L, Zhu, J., and Zhang, R. (2018). Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling.??Journal of the American Society of Nephrology : JASN. 2017121275.

3. Weng, Z, Situ, C, Lin, L, Wu, Z, Zhu, J., and Zhang, R. (2018). Structure of BAI1/ELMO2 complex reveals a general action mode of adhesion GPCRs via ELMO family scaffolds. Nature?Communications.?(accepted)

4. Zhu, J., Zhou, Q., Shang, Y., Li, H., Peng, M., Ke, X., Weng, Z., Zhang, R., Huang, X., Li, S.S.C.,?Feng, G, Zhang, M.?(2017). Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell reports?21, 3781-3793

研究方向

結構生物學
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